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The .25ACP is likely the least effective centerfire handgun cartridge ever produced. However, any gun is better than no gun in a defensive situation where deadly force is justified. In addition, firearms chambered for this cartridge are among the smallest with regard to physical dimensions, so there is less of an excuse not to carry the gun due to its physical size.
It is generally advisable to utilize FMJ ammunition for both practice and carry with this caliber, as the penetration depths typical with the expanding types of ammunition usually do not exceed 8", while FMJ bullets can usually be counted on to reach FBI minimum penetration depths.
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